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September 5, 2025Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca

Intra-Articular Use of Hyaluronic Acid Preparations in the Treatment of Knee Osteoarthritis

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Authors

MTMustafa TuranJGJiří Gallo

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Overview

Randomized clinical trials contrast intra-articular hyaluronic acid with PRP and corticosteroids in knee osteoarthritis, suggesting various benefits.

Key Points

  • Hyaluronic acid treatment shows moderate relief in knee osteoarthritis symptoms at six months post-administration.
  • Platelet-rich plasma injections provided the greatest effect and longevity of symptom relief compared to corticosteroids and hyaluronic acid.
  • Corticosteroid administration offers rapid pain relief, but effects diminish significantly after one month following treatment.
  • Previous guidelines from the ACR and NICE express caution regarding the use of hyaluronic acid in knee osteoarthritis management.

Cite This Study

Turan et al. (2025) studied this question.

synapsesocial.com/papers/68c23887b210217d6477845fhttps://doi.org/10.55095/achot2024/065
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