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September 5, 2025eLifeOpen Access

Alteration of long- and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesis

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Authors

KNKatsuyuki NishiTSTaro SakamakiANAkiomi Nagasaka

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Overview

Analysis demonstrates myeloid-biased hematopoiesis in aged mice arises from altered LT-HSC and ST-HSC ratios, suggesting a pivotal role in age-related changes.

Key Points

  • Myeloid-biased hematopoiesis primarily results from altered LT-HSC to ST-HSC ratios in aged mice, not from biased clones.
  • Transcriptomic analysis reveals no significant increase in myeloid genes in aged LT-HSCs compared to young ones, indicating alternate mechanisms.
  • Young HSCs transplanted with aged LT/ST-HSC ratios show increased myeloid output, demonstrating the effect of cellular ratios on lineage bias.
  • Though the bone marrow niche has minimal impact, aged thymi and spleens significantly impair lymphoid hematopoiesis, enhancing myeloid prevalence.

Cite This Study

Nishi et al. (2025) studied this question.

synapsesocial.com/papers/68c23887b210217d647781e3https://doi.org/10.7554/elife.95880.4
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