September 5, 2025Frontiers in EndocrinologyOpen Access

A systematic review and evidence assessment of monogenic gene-disease relationships in human male infertility

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Our findings confirmed 191 gene-disease relationships linked to male infertility, enhancing diagnostic accuracy.
Of 19885 publications screened, 229 were included for analysis, leading to robust associations with infertility.
Utilizing PRISMA protocols, comprehensive data on genetic factors were evaluated from 2020 to 2024 across various infertility studies.
This analysis highlights gaps in evidence for numerous gene-disease relationships, indicating further research is needed.

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Implication

This systematic review identifies gene-disease relationships in male infertility, revealing significant genetic factors affecting reproductive health.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68c23887b210217d64778015 https://doi.org/10.3389/fendo.2025.1643543

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Implication

This systematic review identifies gene-disease relationships in male infertility, revealing significant genetic factors affecting reproductive health.

A systematic review and evidence assessment of monogenic gene-disease relationships in human male infertility

Key Points

Discussion

Implication

Cite This Study

A systematic review and evidence assessment of monogenic gene-disease relationships in human male infertility

Key Points

Discussion

Implication

Cite This Study