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September 5, 2025Frontiers in ImmunologyOpen Access

The alarmin tandem: unraveling the complex effect of S100A8/A9 – from atherosclerosis to cardiac arrhythmias

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Authors

DCDan Alexandru CozacVHVasile-Bogdan HalațiuASAlina Scridon

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Overview

Review explores S100A8/A9's involvement in cardiac arrhythmias and atherosclerosis, suggesting its potential as a therapeutic target.

Key Points

  • S100A8/A9 levels correlate with disease severity in heart failure patients, indicating potential for targeted therapy.
  • The heterodimer S100A8/A9 amplifies vascular inflammation through TLR-4 and RAGE pathways in atherosclerosis.
  • S100A8/A9 is associated with cardiac arrhythmogenesis via mechanisms involving electrical remodeling and fibrosis.
  • Further research on S100A8/A9 may uncover its precise role in cardiovascular diseases and validate therapeutic interventions.

Cite This Study

Cozac et al. (2025) studied this question.

synapsesocial.com/papers/68c23887b210217d64778011https://doi.org/10.3389/fimmu.2025.1630410
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