Observational analysis reveals reduced reproductive function in female offspring, highlighting potential steroidogenic disruption from bisphenol AF exposure during gestation and lactation.
Key Points
Gestational and lactational exposure to bisphenol AF significantly impaired reproductive function in female offspring.
Anogenital distance decreased from 12.05 mm to 11.54 mm in the highest exposure group at postnatal day 21.
Steroid hormone levels of estradiol and testosterone were significantly reduced by postnatal day 70 in exposed female offspring.
BPAF exposure increased follicular atresia and downregulated key steroidogenic gene expressions at postnatal day 70.