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September 5, 2025Journal of PerinatologyOpen Access

Impact of prophylactic antibiotic duration on surgical site infection rate in neonatal surgery: a multicenter retrospective observational study

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Authors

TSTomohiro SunouchiJFJun FujishiroKOKoji Oba

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Overview

Retrospective observational study evaluates surgical site infections related to antibiotic prophylaxis duration in neonates, revealing key risk factors.

Key Points

  • No significant increase in surgical site infections was observed with shorter antibiotic prophylaxis duration in surgical neonates.
  • Of 983 patients analyzed, 91 developed surgical site infections, indicating a 9% infection rate overall.
  • Operative time over 120 minutes, past surgical history, and open surgery were identified as independent risk factors for surgical site infections.
  • This observational study's findings suggest that limiting antibiotic prophylaxis to less than 24 hours is feasible in neonatal surgery.

Cite This Study

Sunouchi et al. (2025) studied this question.

synapsesocial.com/papers/68c23887b210217d64777c04https://doi.org/10.1038/s41372-025-02400-3
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