Enhanced Synovial Fluid Rheology in Moderate Knee Osteoarthritis Through Combined Intra-Articular Hyaluronic Acid and Multimodal Physiotherapy: A Monocentric Observational Study

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Observational study finds that combining hyaluronic acid with physiotherapy enhances synovial fluid rheology in knee osteoarthritis.

The combination of IA-HA and multimodal physiotherapy significantly improves synovial fluid rheological properties.
After six weeks, the pilot group showed enhanced shear viscosity and reduced variability in rheological parameters.
The study included 52 patients with moderate knee osteoarthritis, comparing treatments using a standard rheometer.
These findings suggest that mechanical stimulation can enhance lubrication and homeostasis in affected joints.

Iordan et al. (2025) studied this question.

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