Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 5, 2025Open Access

Indazole–Pyridine Hybrids: Design, Synthesis, and Biological Evaluation as Possible Anticancer Agents against Breast Cancer Cell Lines

View Full Paper
Ask AI
Bookmark
Share

Authors

KPKinjal ParmarBrigham and Women's HospitalIPIshan PanchalAhmedabad University

Discussion

Loading...

Member takes

Implication

Molecular docking reveals potent indazole-pyridine compounds against breast cancer, suggesting future development.

Key Points

  • Compounds 7b and 7c reduced cell viability in MCF-7 breast cancer cells by up to 64%, indicating strong anticancer potential.
  • Molecular docking identified compound 7c as the best binder at –8.7 kcal/mol, outperforming Entrectinib in binding efficacy.
  • ADME predictions suggest high gastrointestinal absorption and good oral bioavailability for indazole-pyridine hybrids.
  • Structural modifications, such as cyclopentyl and halogen substituents, significantly enhance the biological activity of the compounds.

Cite This Study

Parmar et al. (2025) studied this question.

synapsesocial.com/papers/68c2384fb210217d64777426https://doi.org/10.21203/rs.3.rs-7458469/v1
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Cancer statistics, 20242024 · 9,561 citations