September 5, 2025JAMA Cardiology

Clinical Outcomes With Personalized Accelerated Physiologic Pacing in Heart Failure With Preserved Ejection Fraction

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Authors

MIMargaret InfeldUniversity of Vermont JCJamie CyrUniversity of Vermont ANAlexandra E. NovelliDuke University

Discussion

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Implication

Observational analysis reveals adverse event accrual with accelerated pacing in heart failure, suggesting potential benefits compared to standard care.

Key Points

Personalized accelerated pacing was associated with slower accrual of adverse clinical events compared to 60 bpm setting.
In prespecified analysis, myPACE intervention led to 5 adverse events, while usual care had 31, showing significant differences.
Event-free survival was longer in the personalized accelerated pacing group, with a hazard ratio of 0.30 in the 87 patients analyzed.
These findings indicate that personalized approaches may improve clinical outcomes in heart failure patients, warranting further research.

Cite This Study

Infeld et al. (2025) studied this question.

synapsesocial.com/papers/68c2384fb210217d647770ce https://doi.org/10.1001/jamacardio.2025.2827

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Implication

Observational analysis reveals adverse event accrual with accelerated pacing in heart failure, suggesting potential benefits compared to standard care.

Clinical Outcomes With Personalized Accelerated Physiologic Pacing in Heart Failure With Preserved Ejection Fraction

Discussion

Member takes

Implication

Key Points

Cite This Study

Clinical Outcomes With Personalized Accelerated Physiologic Pacing in Heart Failure With Preserved Ejection Fraction

Discussion

Member takes

Implication

Key Points

Cite This Study

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