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September 5, 2025BMC MedicineOpen Access

Development and validation of a postpartum cardiovascular disease risk prediction model in women incorporating reproductive and pregnancy-related predictors

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Authors

SWSteven WambuaFCFrancesca L. CroweSTShakila Thangaratinam

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Overview

Retrospective cohort analysis improves cardiovascular disease risk assessment in postpartum women, indicating significant implications for clinical practices.

Key Points

  • The updated risk prediction model shows better discrimination for cardiovascular disease in postpartum women.
  • Using the QRISK®-3 benchmark, the updated model demonstrated a C-statistic improvement from 0.703 to 0.726.
  • Cox-proportional hazards regression was applied to assess cardiovascular disease risk factors in the postpartum cohort.
  • Improved clinical utility of the updated model suggests it could enhance risk management for postpartum cardiovascular health.

Cite This Study

Wambua et al. (2025) studied this question.

synapsesocial.com/papers/68c2384fb210217d64776a47https://doi.org/10.1186/s12916-025-04229-1
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