August 17, 2025

Advances in Bioinformatics Techniques to Predict Neoantigen: Exploring Tumor Immune Microenvironment and Transforming Data into Therapeutic Insights

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Review explores how bioinformatics enhances neoantigen prediction and tailors cancer treatments, suggesting AI and sequencing technologies are key.

Bioinformatics significantly improves the understanding of tumor-specific antigens, enhancing cancer immunotherapy.
Advanced sequencing technologies like whole-genome and whole-exome sequencing are crucial for assessing mutations leading to neoantigen production.
Innovative methods such as AI, machine learning, and deep learning effectively predict immunogenic neoantigens.
Challenges like tumor heterogeneity and data analysis complexities remain, indicating further advancements are essential.

Abdulwahed Alrehaily (2024) studied this question.

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Review explores how bioinformatics enhances neoantigen prediction and tailors cancer treatments, suggesting AI and sequencing technologies are key.