August 17, 2025Molecular visionOpen Access

The interactions between ARMS2, CFH, VEGF-A and environmental factors on the risk of age-related macular degeneration

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Discussion

Case-control study examines polymorphisms in ARMS2, CFH, and VEGF-A genes linked to AMD risk.

People with specific gene variants faced a significantly higher risk for developing age related macular degeneration.
The T allele of ARMS2 rs10490924 showed an odds ratio of 5.08 for AMD compared to controls.
Statistical analyses utilized methods such as allele-specific PCR and STATA software for reliable results.
Increased AMD risk may prompt further studies focusing on ethnic groups in different populations.

Altankhuyag et al. (2024) studied this question.

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