Mesopic and Low-Contrast Visual Acuity Deficits in Retinitis Pigmentosa: Clinical Markers for Early Functional Impairment

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Discussion

Observational study highlights early visual dysfunction in retinitis pigmentosa patients, indicating low-contrast testing improves diagnosis.

Significant visual acuity loss was observed in retinitis pigmentosa patients under reduced luminance and contrast, emphasizing early detection.
Mesopic low-contrast deficit showed the highest diagnostic accuracy with an AUC of 0.87, indicating its potential as an effective clinical marker.
The study involved 57 retinitis pigmentosa patients compared to 54 controls, assessing binocular visual acuity under various lighting conditions.
Low-contrast visual acuity under mesopic conditions correlates with functional symptoms, enhancing disease monitoring and early detection.

Cedrún‐Sánchez et al. (2025) studied this question.

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Observational study highlights early visual dysfunction in retinitis pigmentosa patients, indicating low-contrast testing improves diagnosis.