August 17, 2025

Enhanced Wound Healing and Anti-Inflammatory Effects of Vitamin C-Loaded Hyaluronic Acid–Collagen Scaffolds in Preclinical Rat Models

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Wound healing was significantly enhanced by the vitamin C-loaded scaffold, improving tissue regeneration.
Incorporation of vitamin C in the scaffold led to a notable reduction in inflammatory markers and better fibroblast activity.
This research utilized preclinical rat models to assess the efficacy of a hyaluronic acid-collagen scaffold enriched with vitamin C.
Findings suggest the potential of this multifunctional scaffold for improved clinical applications in wound management.

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Preclinical analysis reveals vitamin C boosts fibroblast activity and reduces inflammation in wound healing.

Salem et al. (2025) studied this question.

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