Interstitial Lung Disease in Mixed Connective Tissue Disease: Clinical Profile and Disease Spectrum

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Discussion

Retrospective analysis identifies common symptoms and autoantibody patterns in MCTD with ILD, suggesting further study is warranted.

Most patients with mixed connective tissue disease and interstitial lung disease are young females, showing a distinct clinical profile.
Non-specific interstitial pneumonia occurred in 17 patients, while usual interstitial pneumonia was found in 5 patients.
Assessment of medical records revealed high autoantibody positivity, particularly ANA in 95.5% of cases, indicating immune involvement.
Frequent features included Raynaud's phenomena and arthritis, highlighting the need for comprehensive evaluation in MCTD patients with ILD.

Butt et al. (2025) studied this question.

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