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August 17, 2025

Some Markers of Chronic Immune Activation in Young Born HIV Positive Under Antiretroviral Treatment at the Yaounde University Teaching Hospital, Cameroon

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Authors

MAMaria Eduarda Guizelini AndréUniversité de Yaoundé I

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Implication

Longitudinal analysis shows rising CD4 and CD8 counts in young HIV patients, suggesting immune activation status influences comorbidities.

Key Points

  • An increase in CD4+ and CD8+ counts was observed, correlating with a CD4:CD8 ratio under 1, indicating chronic immune activation.
  • The study enrolled 74 young participants, with the highest prevalence of comorbidities at the second measurement rising to 50%.
  • A longitudinal prospective analysis assessed immune markers and co-infections using flow cytometry and rapid diagnostic tests.
  • The findings suggest that immunological monitoring in HIV-positive youth, particularly regarding CMV co-infection, is crucial for treatment efficacy.

Cite This Study

Maria Eduarda Guizelini André (2025) studied this question.

synapsesocial.com/papers/68c2366fb210217d6477483fhttps://doi.org/10.63721/25jpmidt0110
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