August 17, 2025Open Access

3D epithelial cell topology tunes signalling range to promote precise patterning

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Epithelial cells enhance signalling range by increasing contact with neighbors at varying heights, leading to improved communication.
The Multi-layer Signalling Model predicts that cell surface signalling is crucial in determining spacing between SOPs in Drosophila.
In vivo experiments show that altering cortical stiffness and cell tortuosity impacts SOP spacing, affirming the model's predictions.
These findings highlight how 3D cell geometry influences the effectiveness of signalling in developmental processes.

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Epithelial cells modify signalling range via 3D topology, indicating the role of notch-delta interaction.

Paci et al. (2025) studied this question.

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