August 16, 2025Open Access

Local homeostasis preserves global neural dynamics compensating for structural loss during human lifespan aging

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Invariant GABA and reduced glutamate maintain functional integration despite structural decline, enhancing brain resilience.
Altered neurotransmitter concentrations are modeled to mimic age-associated connectivity patterns observed in aging populations.
Employing multiscale biophysical modeling with the anatomical connectome allows for detailed insights into brain dynamics across ages.
The findings highlight potential mechanisms for understanding age-related neural disorders and maintaining optimal brain function.

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Modeling reveals altered GABA and glutamate preserve functional connectivity in aging brains, suggesting a compensatory mechanism.

Saha et al. (2025) studied this question.

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