August 16, 2025

HPLC-MS profiling and protective potential of the defatted aqueous methanol extract of two Syzygium species against cadmium chloride-induced nephrotoxicity in rats.

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Defatted extracts significantly reduced inflammatory indicators by 66.8%-75.1%, helping protect against kidney damage.
HPLC-MS profiling identified 62 compounds, highlighting the richness of phenolic metabolites in Syzygium species.
Treatment restored antioxidant markers by 3.3-6 fold at high doses, improving overall kidney health in rats.
The extracts showed safe usage up to 5 g/kg, indicating potential for clinical applications in combating metal toxicity.

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Implication

This study finds that defatted aqueous methanol extracts of Syzygium species improve nephrotoxicity in rats, suggesting their potential therapeutic use against cadmium toxicity.

Cite This Study

Moharram et al. (2025) studied this question.

synapsesocial.com/papers/68c23626b210217d647739f0 https://doi.org/10.1371/journal.pone.0329586

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Implication

This study finds that defatted aqueous methanol extracts of Syzygium species improve nephrotoxicity in rats, suggesting their potential therapeutic use against cadmium toxicity.

HPLC-MS profiling and protective potential of the defatted aqueous methanol extract of two Syzygium species against cadmium chloride-induced nephrotoxicity in rats.

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Implication

Cite This Study

HPLC-MS profiling and protective potential of the defatted aqueous methanol extract of two Syzygium species against cadmium chloride-induced nephrotoxicity in rats.

Key Points

Discussion

Implication

Cite This Study