A Green Approach to Antifungal Therapy: Formulation and Evaluation of Clitoria ternatea-Based Cream

Introduction: Clitoria ternatea, a medicinal plant, has been traditionally used for its various therapeutic properties, including antifungal, anti-inflammatory, and antioxidant effects. The present study aimed to evaluate the antifungal potential of Clitoria ternatea seed extract incorporated into a cream formulation, with an emphasis on phytochemical screening, antifungal activity, and formulation characterization. Materials and Methods: The Clitoria ternatea seeds were collected, extracted using water and methanol, and subjected to various phytochemical tests to detect alkaloids, flavonoids, tannins, phenols, and amino acids. The cream formulations were prepared as oil-in-water (O/W) emulsions, incorporating Gokarn and a mixture of plant extracts. Antifungal activity was evaluated by the disc diffusion method, testing against Candida albicans (ATCC 90028). The prepared creams were assessed for parameters such as appearance, pH, homogeneity, spreadability, irritancy, and washability. Results: Phytochemical analysis confirmed the presence of alkaloids, flavonoids, tannins, phenols, and amino acids in the Clitoria ternatea extract. FTIR studies revealed characteristic functional groups in the extract and the formulation. Antifungal testing showed that the cream with Gokarn exhibited a significant zone of inhibition, though smaller than the positive control (marketed antifungal cream). The cream formulations were homogeneous, non-irritating, and easily spreadable, with satisfactory emolliency and washability. Conclusion: The results suggest that Clitoria ternatea seed extract possesses significant antifungal potential. The formulated cream showed promising results, with good physical properties and therapeutic potential for skin-related conditions. Further clinical studies are recommended to optimize the formulation for broader applications.