August 16, 2025Journal of Complementary and Alternative Medical ResearchOpen Access

Toxicological Evaluation of Chronic Administration of Zea mays Husk Extract on Female Rats

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Authors

JOJude E. OkokonUniversity of Uyo JUJohn A. UdobangUniversity of Uyo COChinyelu C. Osigwe

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Implication

Observational analysis shows mild effects on liver function and hematological indices in female rats, suggesting caution with high doses of husk extract.

Key Points

Significant reduction in bleeding time was observed in female rats treated with 374 mg/kg of husk extract, indicating a possible effect on blood coagulation.
Total cholesterol and VLDL levels were significantly lowered in rats given lower and higher doses of the extract, emphasizing its impact on lipid profile.
Chronic treatment involved daily doses for 100 days, assessing effects on body weight, organ function, and hematological indices compared to the control group.
The extract shows mild to moderate histological effects on multiple organs, particularly the ovaries, highlighting the need for careful dosage considerations.

Cite This Study

Okokon et al. (2025) studied this question.

synapsesocial.com/papers/68c235fdb210217d64772b36 https://doi.org/10.9734/jocamr/2025/v26i8693

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Implication

Observational analysis shows mild effects on liver function and hematological indices in female rats, suggesting caution with high doses of husk extract.

Toxicological Evaluation of Chronic Administration of Zea mays Husk Extract on Female Rats

Discussion

Member takes

Implication

Key Points

Cite This Study

Toxicological Evaluation of Chronic Administration of Zea mays Husk Extract on Female Rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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