August 16, 2025Open Access

Impact of Neurofibromatosis Type 1 on Executive Functions: A Meta-Analysis Based on the Use of the BRIEF

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Meta-analysis reveals significant executive function deficits in individuals with neurofibromatosis type 1, indicating crucial cognitive challenges.

Executive function impairment is significant in individuals with neurofibromatosis type 1, particularly in behavioral regulation.
Effect sizes for executive deficits range from 0.658 to 1.031 for various BRIEF scales, highlighting cognitive struggles.
Systematic review and meta-analysis used BRIEF assessments from multiple studies to analyze executive functions in NF1.
Deficits in executive functions when evaluated with BRIEF are higher than those assessed with BRIEF-P, indicating measurement sensitivity.

Esperanza Báusela Herreras (2025) studied this question.

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Meta-analysis reveals significant executive function deficits in individuals with neurofibromatosis type 1, indicating crucial cognitive challenges.