Oxidative stress in patients with severe asthma

Numerous studies in recent years have demonstrated that oxidative stress (OS) is one of the most important pathophysiologic mechanisms of chronic inflammation in the bronchial wall of asthma patients. OS contributes to chronic inflammation and airway remodeling. The aim of this review was to investigate the role of OS in patients with severe asthma (SA) and therapeutic options for OS improvement based on analysis of literature data from PubMed and Google Scholar databases for the period 2020 – 2025. Methods. 83 PubMed and Google Scholar publications were selected for the review by searching the following keywords: oxidative stress in SA, OS treatment in SA, and antioxidant therapy in SA. Conclusion. OS plays a crucial role in the pathogenesis of SA, contributing to the formation and maintenance of chronic inflammation in the bronchial wall, bronchial hyperreactivity and remodeling, persistence of symptoms, and decreased ventilatory function of the lungs. Search and development of innovative treatment methods aimed at reducing the severity of OS in the bronchial wall, in particular inhalation therapy with a thermal helium-oxygen mixture, may be of particular interest in the complex therapy of SA in order to establish the most comprehensive control of the disease.