August 15, 2025BoneOpen Access

Mortality and fracture risk in children with osteogenesis imperfecta: Results from the French nationwide hospital discharge database

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Newborns with osteogenesis imperfecta have significantly higher immediate and long-term mortality compared to infants and children.
Of the 658 children analyzed, 12.0% died during the study, with immediate mortality highest among newborns at 30.2%.
This analysis utilized retrospective data from the French nationwide hospital discharge database focusing on health claims and outcomes.
The findings suggest ongoing healthcare challenges despite existing national guidelines for managing osteogenesis imperfecta.

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Cohort analysis shows high mortality and fracture risk in children with osteogenesis imperfecta, highlighting severe challenges.

Philippoteaux et al. (2025) studied this question.

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