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August 15, 2025КАРДИОЛОГИЯ УЗБЕКИСТАНАOpen Access

Aspirin or P2Y12 Inhibitor Monotherapy After Percutaneous Coronary Intervention for Acute Coronary Syndromes

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Authors

CLClaudio LaudaniDGDaniele GiacoppoGOG. Occhipinti

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Overview

Randomized trials comparing aspirin and P2Y12 inhibitor monotherapy show differing outcomes for adverse events in ACS.

Key Points

  • P2Y12 inhibitor monotherapy reduces net adverse clinical events (NACE) significantly compared to aspirin monotherapy, highlighting its potential benefits.
  • Among 45,394 patients, P2Y12 inhibitor monotherapy notably lowers any bleeding and major bleeding incidents compared to aspirin monotherapy during short DAPT.
  • Network meta-analyses indicate significant differences in outcomes between aspirin and P2Y12 inhibitor monotherapy for patients with acute coronary syndrome after PCI.
  • Short DAPT duration benefits varied based on the type of monotherapy, emphasizing the need for personalized treatment approaches in ACS management.

Cite This Study

Laudani et al. (2025) studied this question.

synapsesocial.com/papers/68c235ccb210217d64771ea3https://doi.org/10.1016/j.jcin.2025.05.044
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Short- Versus Standard-Duration Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in Acute Coronary Syndrome: A Systematic Review and Meta-Analysis2026
  2. 2Sequential administration of abbreviated (up to one month) dual antiplatelet therapy and Ticagrelor monotherapy versus standard dual antiplatelet therapy after percutaneous coronary intervention: A meta-analysis2025
  3. 3One‐Year Outcomes of Short‐Term Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention With Drug‐Eluting Stents: A Meta‐Analysis of Randomized Clinical Trials2025
  4. 4Antiplatelet Monotherapies for Long-Term Secondary Prevention Following Percutaneous Coronary Intervention2025 · 7 citations
  5. 5Early Withdrawal of Aspirin after PCI in Acute Coronary Syndromes2025 · 77 citations