August 15, 2025MoleculesOpen Access

Doxorubicin Toxicity and Recent Approaches to Alleviating Its Adverse Effects with Focus on Oxidative Stress

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Discussion

Review discusses doxorubicin toxicity management in oncological diseases, highlighting oxidative stress and nanotechnology.

Doxorubicin exposure leads to multiple toxic effects, notably cardiotoxicity, hepatotoxicity, and nephrotoxicity.
Significant strategies include encapsulating doxorubicin in nanoparticles, which maintain antitumor efficacy while reducing toxicity.
Innovative approaches such as simultaneous antioxidant delivery are analyzed to alleviate oxidative stress associated with doxorubicin.
Findings highlight the need for improved therapies in oncological diseases to minimize doxorubicin's adverse effects.

Radeva et al. (2025) studied this question.

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