August 15, 2025Open Access

Viral Diversity Influences T Cell Responses to Enteric Human Adenoviruses F40 and F41

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Analysis reveals how viral diversity influences T cell and cytokine responses to HAdV infection, suggesting implications for vaccine design.

Predicted CD8 + T cell epitopes shared among adenovirus species enhance immune responses, leading to potential protection.
Among the F41 hexon peptides tested, 11 of 16 elicited positive IFNγ responses from healthy adult donors.
Assessment of MHC-peptide binding suggests evolutionary changes in adenovirus capsid proteins affecting immune response.
Findings highlight the importance of T cell recognition in understanding adenovirus evolution and vaccine development.

Craven et al. (2025) studied this question.

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Analysis reveals how viral diversity influences T cell and cytokine responses to HAdV infection, suggesting implications for vaccine design.