August 14, 2025

Limited predictive value of pretreatment P-glycoprotein immunostaining for chemotherapy efficacy and survival in long-follow-up osteosarcoma patients.

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Authors

THTakashi Higuchi KIKentaro Igarashi SMShinji Miwa

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Implication

Retrospective analysis shows no association between P-glycoprotein expression, chemotherapy response, and overall survival in osteosarcoma patients, suggesting limited predictive utility.

Key Points

P-glycoprotein expression did not significantly correlate with chemotherapy response or survival outcomes in osteosarcoma patients.
Patients with varied P-glycoprotein levels showed similar overall survival and disease-free survival results.
This retrospective cohort analysis involved 23 patients treated between 2007 and 2013 with biopsy-based P-glycoprotein assessments.
Findings indicate the need for more reliable biomarkers for chemotherapy efficacy and prognosis in osteosarcoma.

Cite This Study

Higuchi et al. (2025) studied this question.

synapsesocial.com/papers/68c235ccb210217d64771cb3 https://doi.org/10.1097/md.0000000000043472

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Implication

Retrospective analysis shows no association between P-glycoprotein expression, chemotherapy response, and overall survival in osteosarcoma patients, suggesting limited predictive utility.

Limited predictive value of pretreatment P-glycoprotein immunostaining for chemotherapy efficacy and survival in long-follow-up osteosarcoma patients.

Discussion

Member takes

Implication

Key Points

Cite This Study

Limited predictive value of pretreatment P-glycoprotein immunostaining for chemotherapy efficacy and survival in long-follow-up osteosarcoma patients.

Discussion

Member takes

Implication

Key Points

Cite This Study

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