Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
August 14, 2025eJHaemOpen Access

Targeted Degradation of Class 1 HDACs With PROTACs is Highly Effective at Inducing DLBCL Cell Death

View Full Paper
Ask AI
Bookmark
Share

Authors

AAAbdullah AlraddadiJSJoshua P. SmalleyWAWael Alzahrani

Discussion

Loading...

Member takes

Overview

Novel PROTAC demonstrates significant cell death in DLBCL, suggesting new therapeutic strategies for treatment.

Key Points

  • Targeted degradation of class I hdacs significantly induces cell death in dlbcl cells, promoting apoptosis and DNA damage.
  • Using a proteolysis targeting chimera, this approach outperformed standard hdac inhibitors alone in various cell lines.
  • Assessment through proteomics reveals mechanisms behind cell death, highlighting pro-apoptotic protein activation and survival pathway inhibition.
  • Further research is warranted to evaluate the clinical relevance of this targeted therapy for dlbcl patients.

Cite This Study

Alraddadi et al. (2025) studied this question.

synapsesocial.com/papers/68c235ccb210217d64771c3ahttps://doi.org/10.1002/jha2.70127
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epigenetic therapy meets targeted protein degradation: HDAC-PROTACs in cancer treatment2025 · 9 citations
  2. 2HDAC inhibitors potentiate the efficacy of antineoplastic agents in acute megakaryoblastic leukemia via dual activation of apoptosis and pyroptosis2025
  3. 3Combination of HDAC inhibitor and PI3K inhibitor suppresses autophagy and induces apoptosis via cytoplasmic IκBα stabilization in p53-mutant diffuse large B-cell lymphoma2025
  4. 4Synthetic Lethal Combinations of DNA Repair Inhibitors and Genotoxic Agents to Target High‐Risk Diffuse Large B Cell Lymphoma2025
  5. 5Targeted histone deacetylase degradation via chemical induced proximity by direct recruitment of the CUL4 complex adaptor protein DDB12025