Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 14, 2025European Heart JournalOpen Access

Titin-related familial dilated cardiomyopathy: factors associated with disease onset

View Full Paper
Ask AI
Bookmark
Share

Authors

RJRenée JohnsonRFRobert A. FletcherSPStacey Peters

Discussion

Loading...

Member takes

Overview

Retrospective analysis reveals strong association between clinical risk factors and dilated cardiomyopathy onset in families with TTN gene variants, suggesting intervention may improve outcomes.

Key Points

  • TTNtv-positive subjects were 21-fold more likely to develop dilated cardiomyopathy than those without variants, highlighting the genetic risk.
  • The presence of clinical risk factors increased the likelihood of developing dilated cardiomyopathy, especially in younger patients under 30 years.
  • Shared frailty models were employed to analyze factors associated with disease onset in families with TTN gene variants, emphasizing a nuanced approach.
  • Early administration of beta-adrenergic blockers or renin-angiotensin blockers significantly reduced the odds of developing dilated cardiomyopathy, supporting preventative care.

Cite This Study

Johnson et al. (2025) studied this question.

synapsesocial.com/papers/68c235ccb210217d64771acchttps://doi.org/10.1093/eurheartj/ehaf380
View Full Paper
Ask AI
Bookmark
Share