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August 14, 2025The OncologistOpen Access

Characterization of a novel comprehensive genomic profiling test with better detection of heterozygous deletions and RNA-based gene fusion analysis

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Authors

RKRyouta KakutaATAkira TakemotoKTKousuke Tanimoto

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Overview

Observational analysis shows improved detection of gene fusions and deletions in cancer using ACTOnco+, indicating its potential for personalized medicine.

Key Points

  • ACTOnco+® identified 329 heterozygous deletions, demonstrating reliability with FISH analysis, and providing a robust genomic profile.
  • Positive agreement in actionable genes was 82.8% between ACTOnco+® and FoundationOne® CDx across 110 samples from 29 tumor types.
  • Comparison involved RNA and DNA analysis with high concordance in tumor mutational burden and microsatellite instability measurements.
  • The findings suggest that incorporating RNA analysis can enhance cancer genomic profiling for improved treatment strategies.

Cite This Study

Kakuta et al. (2025) studied this question.

synapsesocial.com/papers/68c23595b210217d64771969https://doi.org/10.1093/oncolo/oyaf056
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