Retrospective cohort study finds lower neonatal sepsis rates with ampicillin-tobramycin in chorioamnionitis treatment.
Key Points
A lower rate of early-onset neonatal sepsis was observed with ampicillin-tobramycin compared to ceftriaxone-metronidazole, suggesting improved neonatal safety.
In the analysis of 459 maternal-neonatal dyads, 276 received ceftriaxone-metronidazole and 183 received ampicillin-tobramycin, highlighting a significant cohort size.
Logistic regression and propensity score weighting ensured balanced comparison of antibiotic regimens, confirming the robustness of findings.
The results support ampicillin-tobramycin with metronidazole as a preferred choice for treating clinical chorioamnionitis, indicating clinical implications for maternal care.