August 14, 2025Open Access

Deriving longitudinal tumor phylogenies from single-cell sequencing data

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Algorithm P hyllochron builds longitudinal phylogenies from tumor cells, indicating rare clones persist through treatment.

P hyllochron demonstrates improved reconstruction of tumor phylogenies, revealing rare clones missed by prior methods.
Active analysis of longitudinal single-cell sequencing data has shown significant support for rare cancer clones.
The algorithm employs a unique mathematical formulation of perfect phylogeny, enhancing analytical accuracy.
Findings highlight the necessity for robust phylogenetic methods in understanding tumor evolution during treatment.

Jakatdar et al. (2025) studied this question.

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August 14, 2025Open Access

View Full Paper

Ask AI

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Authors

Algorithm P hyllochron builds longitudinal phylogenies from tumor cells, indicating rare clones persist through treatment.

P hyllochron demonstrates improved reconstruction of tumor phylogenies, revealing rare clones missed by prior methods.
Active analysis of longitudinal single-cell sequencing data has shown significant support for rare cancer clones.
The algorithm employs a unique mathematical formulation of perfect phylogeny, enhancing analytical accuracy.
Findings highlight the necessity for robust phylogenetic methods in understanding tumor evolution during treatment.

Jakatdar et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark