Mitochondrial Dysfunction in Aging: Future Therapies and Precision Medicine Approaches

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Systematic review highlights mitochondrial dysfunction links to aging and explores innovative precision therapies for age-related diseases.

Aging decreases mitochondrial efficiency, leading to various health issues, particularly neurodegenerative and cardiovascular diseases.
Key mechanisms include increased reactive oxygen species and impaired oxidative phosphorylation due to mitochondrial decline.
The review systematically explores therapeutic strategies including nanodelivery systems and CRISPR/Cas9 gene editing for mitochondrial problems.
Insights suggest precision mitochondrial medicine could significantly improve health outcomes and foster healthy aging.

Jia et al. (2025) studied this question.

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Systematic review highlights mitochondrial dysfunction links to aging and explores innovative precision therapies for age-related diseases.