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August 11, 2025Journal of Cancer BiologyOpen Access

Mechanisms of cancer cell rescue against pancreatic cancer therapeutics: Intrinsic and acquired resistance

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Authors

JGJeevan GhosalkarVSVinay R. SonawaneKJKalpana Joshi

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Overview

This review identifies intrinsic and acquired resistance in pancreatic cancer therapies, suggesting new strategies to enhance effectiveness.

Key Points

  • Resistance to pancreatic cancer treatments is a major barrier to improved outcomes, affecting many patients.
  • The review discusses intrinsic and acquired resistance involving genetic and epigenetic changes along with drug metabolism.
  • Cell cycle dysregulation and tumor microenvironment factors contribute significantly to therapeutic resistance.
  • Understanding resistance mechanisms is essential for developing better treatment strategies and improving patient prognosis.

Cite This Study

Ghosalkar et al. (2025) studied this question.

synapsesocial.com/papers/68c2354db210217d6476fcf0https://doi.org/10.46439/cancerbiology.6.070
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