August 11, 2025F1000ResearchOpen Access

The potential effects of cranberry extract on indomethacin-induced gastric ulcer in rats

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Discussion

Cranberry extract reduces gastric ulcer severity in rats exposed to indomethacin, suggesting protective benefits.

Cranberry extract significantly ameliorated gastric ulcerations in indomethacin-exposed rats, improving tissue health.
After treatment, rats showed lower serum inflammatory markers like TNF-α and IL-6, indicating reduced inflammation.
Treatment involved administering cranberry extract alongside indomethacin in a controlled animal model over 15 days.
These findings highlight the potential of cranberry's anti-inflammatory properties to counteract NSAID-induced gastric damage.

Abdul-Majeed et al. (2025) studied this question.

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