August 26, 2025Scientific ReportsOpen Access

Higher proportion of coagulative necrosis and PD-L1+ immune cells in splenic tuberculosis

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Splenic tuberculosis shows a higher incidence of coagulative necrosis than pulmonary tuberculosis, highlighting distinct pathology.
CT scans indicate that splenic tuberculosis mainly results in significant spleen enlargement with low-density shadows visible.
Infiltrating immune cells like T cells and CD8+ T cells increase in splenic tuberculosis, though immune response impact appears minimal.
PD-L1+ immune cell numbers are significantly elevated in splenic tuberculosis compared to both pulmonary tuberculosis and normal spleen tissue.

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Analysis reveals higher coagulative necrosis and PD-L1+ immune cells in splenic tuberculosis cases, indicating unique immune responses.

Dai et al. (2025) studied this question.

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