P71 | Cardiovascular effects of Bruton’s tyrosine kinase inhibitor in chronic lymphocytic leukemia: an advanced echocardiographic study

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Observational analysis shows cardiac stability in CLL patients on Ibrutinib, indicating no worsening of atrial strain.

No significant changes in echocardiographic parameters were observed at the six-month follow-up, indicating cardiac stability.
Study evaluated 26 CLL patients using advanced echocardiography including myocardial work metrics like global work index.
Findings suggest that Ibrutinib does not worsen atrial remodeling, allowing continued treatment.
Hypothesizing a beneficial effect of blood pressure on cardiac performance, though results were not statistically significant.

A 2025 study studied this question.

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