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August 26, 2025Current Issues in Molecular BiologyOpen Access

The Molecular Mechanism of Craniofacial Cartilage Deformity Induced by High Glucose in Zebrafish

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Authors

XCXiaomei ChenYHYong HuangXYXin Yang

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Overview

Zebrafish model reveals high glucose disrupts craniofacial development via oxidative stress in gestational diabetes.

Key Points

  • Craniofacial cartilage malformations occurred with high glucose exposure, indicating severe developmental impact.
  • Zebrafish embryos treated with 3.5% and 4% glucose showed significant growth retardation and cartilage deformities.
  • Molecular assays highlighted that oxidative stress and ROS accumulation caused downregulation of key cranial neural crest cell markers.
  • Findings suggest impaired craniofacial development linked to gestational diabetes, emphasizing therapeutic targets for oxidative stress.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68af7dfe7567bf4f94ff539ahttps://doi.org/10.3390/cimb47090687
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