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August 26, 2025Current Issues in Molecular BiologyOpen Access

The Molecular Mechanism of Craniofacial Cartilage Deformity Induced by High Glucose in Zebrafish

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Authors

XCXiaomei ChenYHYong HuangXYXin Yang

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Overview

Zebrafish model reveals high glucose disrupts craniofacial development via oxidative stress in gestational diabetes.

Key Points

  • Craniofacial cartilage malformations occurred with high glucose exposure, indicating severe developmental impact.
  • Zebrafish embryos treated with 3.5% and 4% glucose showed significant growth retardation and cartilage deformities.
  • Molecular assays highlighted that oxidative stress and ROS accumulation caused downregulation of key cranial neural crest cell markers.
  • Findings suggest impaired craniofacial development linked to gestational diabetes, emphasizing therapeutic targets for oxidative stress.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68af7dfe7567bf4f94ff539ahttps://doi.org/10.3390/cimb47090687
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Overload of Glucose Metabolism as Initiating Factor in Diabetic Embryopathy and Prevention by Glyoxalase 1 Inducer Dietary Supplement2025
  2. 2Dual Disruption of Embryonic Angiogenesis by Hyperglycemia: Structural and Hemodynamic Alterations Revealed via <scp>OCT</scp> Angiography and Biospeckle Imaging in the Chick <scp>CAM</scp> Model2025
  3. 3HOXA13 promotes high glucose-induced trophoblast cell growth and migration during gestational diabetes by regulating the smad2 pathway2025
  4. 4Intrauterine hyperglycemia impairs mouse primordial germ cell development and fertility by sex-specific epigenetic reprogramming interference2025
  5. 5Comparison of the Differing Impacts of Lowered N-Acetylglucosaminyltransferase-Ia/b Activity on Motor and Sensory Function in Zebrafish2025