August 1, 2025BMJ OpenOpen Access

Serial cardiac magnetic resonance imaging to assess myocardial inflammation in PET-positive cardiac sarcoidosis under immunomodulatory therapy: a retrospective observational study

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Discussion

Retrospective analysis highlighted shifts in cardiac MRI metrics in patients with active sarcoidosis, suggesting monitoring potential.

In patients with active sarcoidosis, cardiac MRI changes indicated reduced myocardial inflammation during treatment.
Global T2 reduction was significant, showing median decreases from 39 ms to 37 ms after immunomodulatory therapy, p=0.002.
The observational cohort study included 24 participants with PET-confirmed inflammation, emphasizing the need for further research.
Findings support the potential of cardiac MRI to monitor inflammation in sarcoidosis, although causal effects remain unconfirmed.

Vietheer et al. (2025) studied this question.

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August 1, 2025BMJ OpenOpen Access

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Authors

Retrospective analysis highlighted shifts in cardiac MRI metrics in patients with active sarcoidosis, suggesting monitoring potential.

In patients with active sarcoidosis, cardiac MRI changes indicated reduced myocardial inflammation during treatment.
Global T2 reduction was significant, showing median decreases from 39 ms to 37 ms after immunomodulatory therapy, p=0.002.
The observational cohort study included 24 participants with PET-confirmed inflammation, emphasizing the need for further research.
Findings support the potential of cardiac MRI to monitor inflammation in sarcoidosis, although causal effects remain unconfirmed.

Vietheer et al. (2025) studied this question.

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