Experiments reveal diastereoselective cycloaddition and Michael addition of isatin ketonitrones with chalcones, suggesting new synthetic pathways for oxoindoles.
The synthesis of novel spiropyrrolidine oxoindole/γ-substituted isatin ketonitrone derivatives was reported, using [3+2]-cycloaddition/Michael addition of isatin ketonitrones 1,3-dipoles, generated from the condensation of isatins and arylhydroxylamines, with chalcones under base-controlled...
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Cheng et al. (2025) studied this question.