August 26, 2025CureusOpen Access

Non-endoscopic Biomarkers and Sampling for Diagnosis and Monitoring of Adult Eosinophilic Esophagitis: A Systematic Review and Pooled Analysis

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Moderate sensitivity (70-75%) and specificity (56-86%) observed for liquid-based cytology in diagnosing eosinophilic esophagitis.
Significant reduction in absolute eosinophil count was reported in treated adults with eosinophilic esophagitis.
Analysis included sixteen studies assessing biomarkers and sampling methods for eosinophilic esophagitis diagnosis.
Findings indicate that non-endoscopic tools may augment histologic evaluation, but larger validation studies are necessary.

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Systematic review demonstrates biomarkers and sampling tools for EoE diagnosis, suggesting further validation needed.

Nguyen et al. (2025) studied this question.

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