Hepatitis autoinmune seronegativa. A propósito de un caso

Autoimmune hepatitis (AIH) is a rare, chronic, inflammatory and necrotic liver disease characterized by the presence of autoantibodies. Its etiology is unknown. It affects 1 in 200,000 people annually in the United States3, predominantly women. Its presentation varies from asymptomatic forms to cirrhosis and acute liver failure. Diagnosis is based on the measurement of autoantibodies, such as autoantinuclear antibodies (ANA), anti-smooth muscle antibodies (ASMA), and anti-liver and kidney microsomal antibodies (anti-LKM-1). 10% of HAIs do not present antibodies, being called seronegative HAI, requiring a liver biopsy for diagnosis. Today there is no established algorithm for the diagnosis of this variant. Next, a bibliographic review will be carried out on the topic and presentation of the case of a 63 years old woman with a history of arterial hypertension, who presented asthenia, adynamic, acholia and generalized mucocutaneous jaundice, in which laboratory evidence was performed. of hypertransaminemia, a diagnosis of advanced chronic liver disease was made through biopsy and subsequently a diagnosis of autoimmune hepatitis was made due to negativity of antibodies to finally be treated with corticosteroids and azathioprine, resulting in resolution of the condition.