Randomized clinical trial comparing removal followed by topical imiquimod versus removal followed by topical methylprednisolone in the treatment of keloids

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Randomized trial shows similar efficacy for imiquimod and methylprednisolone in keloid treatment, suggesting new options.

Surgical removal plus topical imiquimod shows comparable efficacy to methylprednisolone for treating keloids, with no significant differences in recurrence rates.
In this study, 3 out of 8 keloids treated with imiquimod recurred compared to 4 out of 8 in the methylprednisolone group within a year after treatment.
Conducted as a randomized, double-blind trial involving 10 patients with paired keloid lesions, each receiving different topical treatments.
These findings suggest that imiquimod could be a viable option as an additional therapy for recurrent keloids, indicating a need for further research.

Ricciardi et al. (2025) studied this question.

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