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August 26, 2025MedScienOpen Access

M2 Macrophage Polarization: Signaling Pathways, Metabolic Reprogramming, and Targeting Strategies in Cancer Therapy

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XGXia Guo

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Overview

Analysis reveals M2 macrophage inhibition impacts tumor progression in cancer therapy, suggesting new targeting strategies.

Key Points

  • Targeting M2 macrophage polarization effectively reverses tumor progression.
  • The study outlines key roles of signaling pathways and metabolic reprogramming in M2 macrophages' function.
  • Interventions discussed include modulation through signaling pathway inhibition and exosomal targeting methods.
  • These findings suggest new strategies in cancer therapy by flipping M2 macrophages to an M1 phenotype.

Cite This Study

Xia Guo (2025) studied this question.

synapsesocial.com/papers/68af7c8d7567bf4f94ff3f3bhttps://doi.org/10.61173/0yb1va84
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