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July 1, 2025Research in Pharmaceutical SciencesOpen Access

The beneficial effect of gamma aminobutyric acid on diabetic nephropathy in type 2 diabetic rat model and their offspring

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Authors

HRHossein RezazadehSMSajad Maghareh-DehkordiMTMohammad Vahid Touliat

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Overview

Administration of GABA improves kidney function and reduces hyperglycemia in diabetic rat models, suggesting potential therapeutic benefits.

Key Points

  • GABA treatment decreased blood glucose levels and improved kidney function, signaling a positive impact on diabetic nephropathy.
  • Diabetic parents and their offspring showed improved serum levels of blood urea nitrogen and creatinine after GABA administration.
  • Experiments tracked changes over 16 weeks, revealing significant reductions in insulin resistance and glomerular filtration rate with GABA use.
  • Findings indicate GABA may have therapeutic potential in managing complications associated with type 2 diabetes for generations.

Cite This Study

Rezazadeh et al. (2025) studied this question.

synapsesocial.com/papers/68af7c887567bf4f94ff3b4ahttps://doi.org/10.4103/rps.rps_94_24
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