Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 25, 2025Bulletin of the National Research Centre/Bulletin of the National Research CenterOpen Access

Computational insights into β-catenin–tcf inhibition by bioactive compounds from Cucumis sativus for cancer treatment

View Full Paper
Ask AI
Bookmark
Share

Authors

SOSamson Marvellous OladejiUniversity of Notre DameDCDeborah Ngozi ContehUniversity of IlorinFAFunmilayo Elizabeth AdeyemiBabcock University

Discussion

Loading...

Member takes

Implication

Computational analysis identifies Cucumis sativus compounds that inhibit β-catenin–TCF interaction, indicating potential for drug development.

Key Points

  • Cucumis sativus compounds show strong inhibition of β-catenin–TCF interaction, with specific phytochemicals leading the results.
  • Binding affinity scores reveal Isovitexin-7-O-(6-O-glucosyl)-glucoside as a top inhibitor with −9.811 kcal/mol, showing significant promise.
  • Molecular docking and dynamics simulations confirm the stability of Cu cumerin C with β-catenin, sustaining therapeutic potential.
  • ADMET predictions indicate favorable drug-like properties for select compounds, positioning them as valuable candidates for cancer therapy.

Cite This Study

Oladeji et al. (2025) studied this question.

synapsesocial.com/papers/68af7b2a7567bf4f94ff3519https://doi.org/10.1186/s42269-025-01354-y
View Full Paper
Ask AI
Bookmark
Share