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August 25, 2025PLoS ONEOpen Access

Curative treatment incorporating subjective decisions on age and frailty is not beneficial for older patients with oral cavity squamous cell carcinoma

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Authors

APAlice PrévostHPHugo PoncetVBVictor Benvegnu

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Overview

Retrospective analysis shows deviation from recommended treatment worsens outcomes in older patients with oral cavity squamous cell carcinoma, suggesting guideline adherence is crucial.

Key Points

  • Patients who deviated from the recommended treatment had a significantly lower recurrence-free survival and overall survival within five years.
  • Of 185 patients studied, 79% underwent recommended treatment, while 21% deviated, resulting in worse outcomes.
  • Multivariate logistic regression revealed that deviation from recommended treatment increased postoperative morbidity after three months.
  • The findings highlight the need for validated preoperative risk models to improve treatment decisions for older patients with OCSCC.

Cite This Study

Prévost et al. (2025) studied this question.

synapsesocial.com/papers/68af7b2a7567bf4f94ff3203https://doi.org/10.1371/journal.pone.0330376
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