Cross-sectional analysis examines how cardiorespiratory fitness and visceral adipose tissue impact immune responses among young adults, suggesting important health implications.
Key Points
Low cardiorespiratory fitness and high visceral adipose tissue alter inflammatory response, impairing immune function.
Differentiated T regulatory cells from participants with low fitness showed significantly reduced IL-10 production with mTOR inhibition.
Study utilized DXA, ultrasound, treadmill testing, and accelerometry to assess body composition and fitness levels.
Impacts on immune regulation may suggest therapeutic targets for improving health in those with excess adiposity.