August 25, 2025Frontiers in PharmacologyOpen Access

Recombinant human thrombopoietin improves hematopoietic stem cell differentiation and T-cell immune homeostasis in patients with severe aplastic anemia by upregulating c-MPL

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Discussion

Observational analysis improved T-cell immune homeostasis in patients with aplastic anemia, suggesting rhTPO may aid recovery.

RhTPO improves T-cell immune homeostasis and enhances platelet production in severe aplastic anemia patients with notable effects on CD4 T cells.
Patients receiving rhTPO showed trends of increased platelet counts and higher CD4+/CD8+ T cell ratios, indicating immune response improvement.
Flow cytometry revealed rhTPO upregulated c-MPL expression on hematopoietic stem cells and regulatory T cells in the treated cohort.
Utilizing rhTPO appears promising for restoring immune homeostasis, highlighting its potential therapeutic role for aplastic anemia.

Deng et al. (2025) studied this question.

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